Understanding the Differences between Roxicodone and Oxycodone


When it comes to managing pain, medications like Roxicodone and Oxycodone are frequently prescribed by healthcare providers. Although these two drugs share similarities, it’s crucial to understand their differences to make informed decisions about your pain management plan.


Roxicodone and Oxycodone have the same active ingredient, which is oxycodone hydrochloride. However, Roxicodone is a brand name for immediate-release oxycodone, while Oxycodone refers to both brand name and generic versions of the drug, including extended-release formulations.

Formulation and Administration

Roxicodone is primarily available in tablet form, while Oxycodone comes in various forms, including tablets, capsules, and liquid formulations. Roxicodone is typically taken every 4-6 hours, whereas Oxycodone may have different dosing schedules depending on the specific formulation.


Both Roxicodone and Oxycodone are opioid analgesics used for the management of moderate to severe pain. They are commonly prescribed after surgeries, for chronic pain conditions, or for breakthrough pain in patients already on around-the-clock opioid therapy.

Brand Variations

One of the key differences between Roxicodone and Oxycodone lies in the availability of various brand names. Roxicodone is only available under that specific brand name, while Oxycodone is marketed under different brand names, including OxyContin, Percocet, and Percodan, among others.

Potency and Dosage

The potency of oxycodone medications can vary. Roxicodone, being an immediate-release formulation, is generally considered to have a faster onset of action compared to extended-release Oxycodone formulations. It’s crucial to follow the prescribed dosage instructions carefully to avoid any potential risks associated with these medications.

Possible Side Effects

Both Roxicodone and Oxycodone may cause similar side effects, including drowsiness, constipation, nausea, and respiratory depression. However, since the formulations and dosages can differ, the severity and frequency of these side effects may vary.

Legal Considerations

In legal terms, both Roxicodone and Oxycodone are classified as Schedule II controlled substances due to their potential for abuse and dependence. They should only be used under the supervision of a healthcare professional and as prescribed.


While Roxicodone and Oxycodone share similarities as opioid analgesics, understanding their differences is essential for effective pain management. Always consult with your healthcare provider to determine the most suitable medication and formulation for your specific needs.

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